One of the most aggressive brain tumors, glioblastoma multiforme, remains a major challenge due to its resistance to conventional therapies and high recurrence rates. The LabsinLove spin-off, created by scientists from the ICMAB-CSIC and the University of Granada, aims to revolutionize its treatment using Boron Neutron Capture Therapy (BNCT).
The study, conducted in vivo in mice, reveals tumour reduction and almost complete elimination of metastasis. The compound uses a peptide, called MACTIDE, which is able to precisely target macrophage cells by systemic and oral administration, without accumulation in the liver. The research team has filed a patent application.
Why do organisms sometimes have duplicated or triplicated genes? What can this teach us about evolution and our biology? Cockroaches have up to three copies of the same gene in their genome. Do these copies serve the same function? Why have they retained them?
Quorum Sensing (QS) is the mechanism of chemical communication between bacteria. Researchers are deciphering this language in order to create tools such as this diagnostic kit that is developing a group from IQAC-CSIC, supported by a grant from the EBTon CSIC entrepreneurship award.
Research led by IQAC-CSIC and the University of Barcelona (UB) has developed a new therapeutic tool that inhibits the proliferation of the SARS-CoV-2 virus, which causes COVID-19. This genomic tool can be used to attack other viral diseases that still have no treatment and is an example of the therapeutic potential of oligonucleotides.
Fibrosis (overgrowth of scarred fibrous connective tissue) contributes to 45% of deaths in Western countries and currently has no specific treatment. A new work, led by a team from the CSIC's Barcelona Biomedical Research Institute, identifies the role of the protein cathepsin D in the degradation and remission of fibrotic tissue, which opens up new possibilities for medical treatment
A team from the Institute of Neurosciences in Alicante (CSIC - UMH) has developed and patented a treatment for social disorders, such as anxiety or extreme introversion. It is based on the use of hormones that the brain naturally produces and which, as they have discovered, can regulate behavioral responses related to social interaction.
A team from the Institute of Materials Science of Barcelona (ICMAB) of the CSIC has developed carbon nanocapsules filled with enriched lithium compounds, which can be applied in Neutron Capture Therapy (NCT) for cancer treatment. They are now seeking industrial partners to continue the already patented development.
The Neoleish vaccine, with the participation of the Margarita Salas Biological Research Centre (CIB-CSIC), prevents infection and reduces the presence of the parasite by more than 90%.
