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Last updateSat, 27 Feb 2021 6pm

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BODIPY derivative fluorescent markers that can attach to diverse biomolecules

CSIC scientists have developed and patented an analogous molecule of the PM567 laser colorant. These compounds are stable and can attach to biomolecules by means of ‘click’ chemistry. They can be bond to very diverse molecules and their production process is easily scalable. Main applications are the biomedical ones. Companies of the chemical sector interested in their commercial exploitation are sought.

The compounds developed by the CSIC scientists can be bond to various molecules, such as amino acids, peptides, proteins, lipids, carbohydrates, antibodies, nucleic acids and toxins. Scientists have successfully tested them as markers of bioactive substances.The BODIPYs (which stands for boron dipyrromethene) are fluorescent molecules (or fluorochromes) that have advantageous characteristics such as thermal and photochemical stability, high solubility and robust chemistry.

Researchers study these compounds to use them in chemical sensors, laser dyes and fluorescent markers, active layers on photovoltaic cells, solar collectors or drug carriers, among others.

One of these BODIPYs is PM567, which have excellent photo physical characteristics. Now, CSIC scientists have developed a PM567 analogous, which have the additional advantage that it is even more stable and have in their structure triple bonds that allow their use in chemical reactions of click chemistry.

"Click" chemistry is a synthesis methodology that enables the obtention of complex structures by joining smaller molecules by a certain number of reactions (cycloadditions). It is a methodology that copies nature, in the sense that nature obtains bigger and complex molecules from the sum of small molecules (or modular units) in a quickly, easily, and predictably way.

The compounds can be applied to click chemistry, which enables the obtention of complex structures by joining smaller molecules

The compounds developed by the CSIC scientists can be bond to various molecules, such as amino acids, peptides, proteins, lipids, carbohydrates, antibodies, nucleic acids and toxins. Scientists have successfully tested them as markers of bioactive substances.

They are versatile as can be easily attached to very diverse molecules of biological interest. To obtain them, processes commonly used in the chemical industry can be used therefore industrial scaling should not have special difficulties. Applications are very diverse, although most of them are biomedical.

Contact:

Dra. Patricia Thomas Vielma
Vicepresidencia Adjunta de Transferencia (CSIC)
Tel.: +34 91 568 18 25
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