Wed01272021

Last updateWed, 13 Jan 2021 10am

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A radiotracer to identify and see cholesterol accumulated on vessel walls

A new peptide-based radiotracer has been designed to identify LDL-cholesterol retained and accumulated on the vascular wall of arteries, which can be seen in the very early stages of the disease. The CSIC and the Hospital de Sant Pau are leading this project, which recently was selected in the latest call for grants from the BBVA Foundation for Scientific Research Teams in Biomedicine.

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Cell stimulation device for use in medical prostheses

Scientists at the Microelectronics Institute of Barcelona have developed a device based on nanogenerators for the electrical stimulation of cells, without the need of bulky electrodes or instruments. The advancement has applications in health for bone regeneration in prostheses or the rehabilitation of muscular atrophy.

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Synthetic peptides for fighting metastasis related to the interleukin receptor IL13Rα2

The CSIC has developed a peptide capable of inhibiting the signaling of interleukin 13 mediated by the IL13Rα2 alpha receptor, one of the pathways that contribute metastasis according to recent studies. The synthetic peptide, alone or encapsulated, could be used for the control of metastasis of colon cancer and other tumours such as glioblastoma, as well as in pathologies such as asthma, atopic dermatitis or fibrosis, related to the same receptor, although more assays are required to confirm its efectivity in humans.

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Monitoring mitochondria of living cells to diagnose cancer and other diseases

Scientists from the Institute of Organic Chemistry of the CSIC in Madrid have developed the first fluorescent probe to be introduced in the mitochondria to monitor its function in living cells. A discovery that can have applications in the diagnosis and treatment of pathologies such as cancer, heart disease or diabetes, as well as other mitochondrial diseases.

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New targets and orphan drugs for rare diseases

Scientists at the Centro de Investigaciones Biológicas (CIB) of the CSIC work to find out the genetic diagnosis of rare diseases related to vascular disorders and tumors, as well as to find new therapies. Their research has focused mainly on the HHT disease and the Von Hippel-Lindau syndrome, and they have found out three orphan molecules for treating the HHT disease and one for the treatment of VHL.

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