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Vaccine with fluorescent marker against brucellosis

Researchers from the Institute of Agrobiotechnology and from the Costa Rica University have developed new vaccines which incorporate a fluorescent marker, thus allowing to identify vaccinated animals against brucellosis.

A typical problem of conventional vaccines intended for livestock, and based on live attenuated microorganisms, is that vaccinated animals develop the same antibodies that infected animals, since both (vaccinated and infected) have been exposed to the same pathogen. This is by no means a small problem, as in a emergence infection it is not possible to differentiate, by serological analysis, vaccinated from infected animals. This also makes hard the application of vaccination as a preventive rule, since vaccines make difficult the early detection of outbreaks. Hence the interest in developing systems capable of differentiating an infected animal from a vaccinated animal.

Researchers from the Institute of Agrobiotechnology and from the Costa Rica University have developed new vaccines which incorporate a fluorescent marker, thus allowing to identify vaccinated animals against brucellosis. Development includes new fluorescent vaccines for cattle, sheep and goats, as well the diagnostic kits to distinguish vaccinated animals from animals infected with wild strains. The system makes possible the preventive vaccination without interfering in the detection of disease outbreaks. Researchers seek partners interested in the production of the new vaccines and diagnostic kits.

Contact:

OTT- CSIC
José Manuel González Izquierdo
Telf. 91 568 15 40
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