Last updateThu, 03 Aug 2023 1pm

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Biofunctional dressing to heal critical wounds

Two-layer dressings that facilitate the healing of wounds have been developed by CSIC scientists. The dressings are specially indicated for patients with low blood supply, with diabetes or elderly people. The product has been patented. Industrial partners are sought for license agreements or for keeping on with the research.

Inmunohistoquímica que muestra como en la herida tratada con los apósitos (izquierda) se han reconstruido más vasos sanguíneosScientists at the CSIC, at the Fundación Rioja Salud (FRS) and the University of Alcalá de Henares, in Madrid, have developed a new two-layer dressing to enhance the healing of serious wounds. The dressing, to be used in hospital and health centers,  is especially useful in the case of patients with insufficient blood supply, diabetes or elderly people.


The dressing is composed of two biofunctional layers, made on biocompatible, biodegradable and  dissolvable polymers. These polymer layers act as a support to the active compounds and allow their progressive release.

The activity of some compounds is well known in wound healing processes. Angiogenic factors, which enhance the reconstruction from pre-existing blood vessels; ephitelium rebuilders, that quickly regenerate the damaged tissues; or antimicrobial compounds.

The inner layer of the dressing is an hydrogel that contains a peptid derived from proadrenomedulin, a compound known for its angiogenic and antimicrobial properties, as well as for regenerating the ephitelium. An external layer of polyurethane that contains bemiparin encapsulated in nanoparticles, which are made of biodegradable polymer. Bemiparin is an anticoagulant that acts as a thrombotic and reestenotic modulator.

This system enables a sequential and controlled dosification of both compounds, allowing therefore an effective healing and revascularization. It facilitates the healing process  rebuilding the epithelium and reducing the wound contraction. Also, it has good mechanical properties as the dressing keeps in good state throughout the process.

It can incorporate other layers, such as an adhesive one to fix the dressing.  It is possible also to incorporate more active compounds into the layers, such as growth factors, antibiotics or anti-inflammatory compounds.


Patricia Thomas Vielma
Gestor de Transferencia de Conocimiento
Instituto de Ciencia y Tecnología de Polímeros (ICTP)
Tel.: (+34) 91 561 34 41
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