Sat02272021

Last updateSat, 27 Feb 2021 6pm

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A radiotracer to identify and see cholesterol accumulated on vessel walls

A new peptide-based radiotracer has been designed to identify LDL-cholesterol retained and accumulated on the vascular wall of arteries, which can be seen in the very early stages of the disease. The CSIC and the Hospital de Sant Pau are leading this project, which recently was selected in the latest call for grants from the BBVA Foundation for Scientific Research Teams in Biomedicine.

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New targets and orphan drugs for rare diseases

Scientists at the Centro de Investigaciones Biológicas (CIB) of the CSIC work to find out the genetic diagnosis of rare diseases related to vascular disorders and tumors, as well as to find new therapies. Their research has focused mainly on the HHT disease and the Von Hippel-Lindau syndrome, and they have found out three orphan molecules for treating the HHT disease and one for the treatment of VHL.

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Peptides effective for inhibiting cholesterol aggregation in the vascular wall

A work demonstrates that peptides derived from a LRP1 receptor sequence are very effective inhibiting the aggregation of LDL (low density lipoprotein, also called 'bad' cholesterol) that takes place in the vascular wall during development of atherosclerosis.

Only the introduction is translated

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Artificial intelligence for the diagnosis of rare diseases related to collagen VI

Researchers at the Institute of Robotics and Industrial Informatics -a joint center of the CSIC and the Polytechnic University of Catalonia-, and at the Sant Joan de Déu Hospital in Barcelona, have developed a system for helping in the diagnoses of rare diseases related to deficiencies in the structure of collagen VI.

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A metabolite from a drug against diabetes, a possible treatment for neurodegenerative diseases

MIN-102, a metabolite from a drug against diabetes, could be useful for treating some neurodegenerative diseases, as scientists think. To confirm this hypothesis, a project has been launched with the involvement of the CSIC’s Instituto de Investigaciones Biomédicas de Barcelona, the Hospital Universitari 'Sant Joan de Déu' and the University of Lleida. The research project is led by the company Mynorix Therapeutics.

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